Tianshu

Acupoint name	Acupoint number	Target	Uniprot	References
Tianshu	ST25	TNF	Uniprot link	[1-14]
Tianshu	ST25	IL6R	Uniprot link	[1, 4-8, 10, 12, 15, 16]
Tianshu	ST25	TAC1	Uniprot link	[17-31]
Tianshu	ST25	VIP	Uniprot link	[12, 17-21, 23-25, 27, 31-36]
Tianshu	ST25	mtlA	Uniprot link	[21, 32, 33, 37]
Tianshu	ST25	HTR3A	Uniprot link	[32, 38-42]
Tianshu	ST25	HCRT	Uniprot link	[43]
Tianshu	ST25	HCRTR1	Uniprot link	[43]
Tianshu	ST25	daf-12	Uniprot link	[15]
Tianshu	ST25	FOXP3	Uniprot link	[15]
Tianshu	ST25	TGFBR1	Uniprot link	[6, 15, 44]
Tianshu	ST25	IL10RA	Uniprot link	[3, 5, 6, 9, 15, 16, 44-46]
Tianshu	ST25	IL17RB	Uniprot link	[6, 15]
Tianshu	ST25	POMC	Uniprot link	[47, 48]
Tianshu	ST25	AQP8	Uniprot link	[19]
Tianshu	ST25	AIF1	Uniprot link	[2]
Tianshu	ST25	5-HT4R	Uniprot link	[38, 41]
Tianshu	ST25	CRP	Uniprot link	[49]
Tianshu	ST25	TLR4	Uniprot link	[3, 50, 51]
Tianshu	ST25	TICAM1	Uniprot link	[50]
Tianshu	ST25	TRAF6	Uniprot link	[50]
Tianshu	ST25	IRF3	Uniprot link	[50]
Tianshu	ST25	IKBKB	Uniprot link	[46, 50]
Tianshu	ST25	GAS8	Uniprot link	[21, 33, 52, 53]
Tianshu	ST25	IL1B	Uniprot link	[3, 45, 54-56]
Tianshu	ST25	MYD88	Uniprot link	[3]
Tianshu	ST25	RELA	Uniprot link	[3, 4, 54]
Tianshu	ST25	OCLN	Uniprot link	[54, 57, 58]
Tianshu	ST25	F11R	Uniprot link	[54]
Tianshu	ST25	MUC2	Uniprot link	[54]
Tianshu	ST25	TJP1	Uniprot link	[28, 54, 57, 58]
Tianshu	ST25	PRSS1	Uniprot link	[22]
Tianshu	ST25	KIT	Uniprot link	[59-61]
Tianshu	ST25	TRPV1	Uniprot link	[59, 62-65]
Tianshu	ST25	IL1R1	Uniprot link	[4]
Tianshu	ST25	drd2-a	Uniprot link	[66]
Tianshu	ST25	NFKBIA	Uniprot link	[67]
Tianshu	ST25	AQP1	Uniprot link	[68]
Tianshu	ST25	GRIN1	Uniprot link	[69-71]
Tianshu	ST25	REEP2	Uniprot link	[72]
Tianshu	ST25	VIPR1	Uniprot link	[31, 72]
Tianshu	ST25	PRKACA	Uniprot link	[72]
Tianshu	ST25	PRKCB	Uniprot link	[72]
Tianshu	ST25	PLCG1	Uniprot link	[72]
Tianshu	ST25	P2RX7	Uniprot link	[73]
Tianshu	ST25	SLC6A2	Uniprot link	[42]
Tianshu	ST25	CALCA	Uniprot link	[34-36, 42, 74]
Tianshu	ST25	UCHL1	Uniprot link	[25, 75]
Tianshu	ST25	CXCL8	Uniprot link	[76]
Tianshu	ST25	IL13RA1	Uniprot link	[76]
Tianshu	ST25	KLK5	Uniprot link	[26]
Tianshu	ST25	NPY2R	Uniprot link	[35, 77]
Tianshu	ST25	TRPV2	Uniprot link	[64]
Tianshu	ST25	EDNRB	Uniprot link	[35, 36]
Tianshu	ST25	PTGER3	Uniprot link	[35]
Tianshu	ST25	GJA1	Uniprot link	[78]
Tianshu	ST25	FOS	Uniprot link	[79-81]
Tianshu	ST25	GFAP	Uniprot link	[79, 82]
Tianshu	ST25	KITLG	Uniprot link	[61]
Tianshu	ST25	BAD	Uniprot link	[83]
Tianshu	ST25	IFIH1	Uniprot link	[84, 85]
Tianshu	ST25	SOD3	Uniprot link	[85]
Tianshu	ST25	IGF1	Uniprot link	[55]
Tianshu	ST25	PTGS2	Uniprot link	[56]
Tianshu	ST25	RpS3	Uniprot link	[86]
Tianshu	ST25	C5AR1	Uniprot link	[87]
Tianshu	ST25	NOS1	Uniprot link	[75]
Tianshu	ST25	CHAT	Uniprot link	[75]
Tianshu	ST25	TPH1	Uniprot link	[39, 40]
Tianshu	ST25	IL12RB1	Uniprot link	[6, 13]
Tianshu	ST25	IL23A	Uniprot link	[6]
Tianshu	ST25	IFNG	Uniprot link	[6]
Tianshu	ST25	LBP	Uniprot link	[6]
Tianshu	ST25	COL17A1	Uniprot link	[6]
Tianshu	ST25	TNFRSF1A	Uniprot link	[6, 14]
Tianshu	ST25	TNFRSF1B	Uniprot link	[6, 14]
Tianshu	ST25	IL2RB	Uniprot link	[6]
Tianshu	ST25	HTR4	Uniprot link	[41]
Tianshu	ST25	PROK1	Uniprot link	[88]
Tianshu	ST25	PROKR1	Uniprot link	[88]
Tianshu	ST25	HTR1A	Uniprot link	[89]
Tianshu	ST25	IL18RAP	Uniprot link	[90]
Tianshu	ST25	BRD2	Uniprot link	[9]
Tianshu	ST25	rnp4	Uniprot link	[28]
Tianshu	ST25	CRHR2	Uniprot link	[28, 30, 91]
Tianshu	ST25	CRHR1	Uniprot link	[28]
Tianshu	ST25	TGFB1	Uniprot link	[92]
Tianshu	ST25	TGFBR2	Uniprot link	[92]
Tianshu	ST25	SMAD3	Uniprot link	[92]
Tianshu	ST25	SNAI1	Uniprot link	[92]
Tianshu	ST25	FNDC5	Uniprot link	[92]
Tianshu	ST25	DA1	Uniprot link	[93]
Tianshu	ST25	RT1-Da	Uniprot link	[93]
Tianshu	ST25	P2RX3	Uniprot link	[94-96]
Tianshu	ST25	HDAC8	Uniprot link	[10]
Tianshu	ST25	MPO	Uniprot link	[10, 12]
Tianshu	ST25	GPNMB	Uniprot link	[29]
Tianshu	ST25	LEP	Uniprot link	[11]
Tianshu	ST25	RETN	Uniprot link	[11]
Tianshu	ST25	NPY	Uniprot link	[11]
Tianshu	ST25	AGRP	Uniprot link	[48]
Tianshu	ST25	PRRC2C	Uniprot link	[97]
Tianshu	ST25	SIRT1	Uniprot link	[97]
Tianshu	ST25	PPARG	Uniprot link	[97]
Tianshu	ST25	PPARGC1A	Uniprot link	[97]
Tianshu	ST25	UCP1	Uniprot link	[97]
Tianshu	ST25	PRDM16	Uniprot link	[97]
Tianshu	ST25	TLR2	Uniprot link	[46]
Tianshu	ST25	IRAK1	Uniprot link	[46]
Tianshu	ST25	IFNB1	Uniprot link	[46]
Tianshu	ST25	AMPKalpha-2	Uniprot link	[98]
Tianshu	ST25	STK11	Uniprot link	[98]
Tianshu	ST25	AMPKalpha1	Uniprot link	[98]
Tianshu	ST25	ACACB	Uniprot link	[98]
Tianshu	ST25	POMGNT1	Uniprot link	[99]
Tianshu	ST25	CLDN1	Uniprot link	[57]
Tianshu	ST25	P2RX2	Uniprot link	[95]
Tianshu	ST25	PDYN	Uniprot link	[100]
Tianshu	ST25	IL4R	Uniprot link	[12]
Tianshu	ST25	PNOC	Uniprot link	[101]
Tianshu	ST25	OPRL1	Uniprot link	[101]
Tianshu	ST25	PSORS1C2	Uniprot link	[30, 31]

[1] 黄金,杨静雯,林璐璐,等.不同频率电针天枢穴对术后肠麻痹小鼠胃肠动力和炎症因子的影响[J].辽宁中医杂志,:1-8.

[2] 贺韵涵,李晓峰,符涛,等.针刺干预对肌萎缩侧索硬化症模型小鼠脑及脊髓中 IBA-1和TNF-α表达的影响[J].陕西中医,2020,41(03):292-296.

[3] 李皓月,梁浩.电针天枢穴对溃疡性结肠炎大鼠TLR4/NF-κB信号通路的影响[J].新中医,2018,50(12):20-24.

[4] 吴丹,梁浩.电针天枢穴对溃疡性结肠炎大鼠NF-κB信号通路的影响[J].针灸临床杂志,2018,34(02):56-59+85.

[5] 薛奇明,黄露,李宁.电针天枢穴对重症急性胰腺炎大鼠血清促炎和抗炎因子的影响[J].中西医结合学报,2011,9(06):658-664.

[6] Qi Q,Liu YN,Jin XM, et al.Moxibustion treatment modulates the gut microbiota and immune function in a dextran sulphate sodium-induced colitis rat model[J].World J Gastroenterol,2018,24(28):3130-3144.

[7] Xue QM,Pan H,Huang L, et al.Effects of acupuncture at ST25 on inflammatory mediators and nuclear factor κB activation in a rat model of severe acute pancreatitis[J].Acupunct Med,2015,33(4):299-304.

[8] Xue QM,Huang L,Li N.[Effects of electroacupuncture at Tianshu (ST25) on pro- and anti-inflammatory cytokines in rats with severe acute pancreatitis][J].Zhong Xi Yi Jie He Xue Bao,2011,9(6):658-664.

[9] Xie DP,Zhou GB,Chen RL, et al.Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen[J].Evid Based Complement Alternat Med,2020,2020:1914031.

[10] Yang NN,Ye Y,Tian ZX, et al.Effects of electroacupuncture on the intestinal motility and local inflammation are modulated by acupoint selection and stimulation frequency in postoperative ileus mice[J].Neurogastroenterol Motil,2020,32(5):e13808.

[11] Yu Z,Xia Y,Ju C, et al.Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity[J].Neural Regen Res,2013,8(9):809-816.

[12] Guo H,Zhu SF,Zhang RR, et al.Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis[J].Evid Based Complement Alternat Med,2014,2014:943596.

[13] Wang XM,Lu Y,Wu LY, et al.Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World J Gastroenterol,2012,18(46):6819-6828.

[14] Shi Y,Zhou EH,Wu HG, et al.Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2[J].Chin J Integr Med,2011,17(3):212-217.

[15] 陈明森. 电针“天枢”“足三里”介导FOXP3/DAF通路调控UC大鼠Treg/Th17平衡的机制研究[D] :辽宁中医药大学,2020.

[16] 田浩梅,陈楚淘,陈平国,等.电针不同穴组对溃疡性结肠炎模型大鼠血清IL-6、IL-10含量的影响[J].湖南中医杂志,2012,28(03):123-125.

[17] 陈霞,王宇,仝理,等.艾灸对腹泻型肠易激综合征模型大鼠结肠及下丘脑组织中P物质、血管活性肠肽表达的影响[J].甘肃中医药大学学报,2021,38(01):1-5.

[18] 陆春花,张华梅,陈述芳,等.天枢穴深刺对中风后便秘的临床观察及对血清SP、VIP的调节作用[J].世界科学技术-中医药现代化,2020,22(06):2000-2005.

[19] 杨晓希,武小利,高纺,等.不同穴位艾灸对腹泻模型小鼠腹泻指数及小肠AQP8、VIP及SP表达的影响[J].安徽中医药大学学报,2020,39(02):50-53.

[20] 孟肖蒙,刘晓亭.中药贴敷双侧“天枢”穴对功能性便秘大鼠结肠肌间神经丛血管活性肠肽、P物质的影响[J].针刺研究,2019,44(12):906-910.

[21] 孟肖蒙. 中药贴敷双侧“天枢”穴对功能性便秘大鼠胃肠激素及肠神经递质影响的实验研究[D] :辽宁中医药大学,2019.

[22] 裴丽霞,张伟,宋亚芳,等.电针“天枢”穴对感染后肠易激综合征内脏高敏感模型大鼠结肠肥大细胞活化和P物质的影响[J].针刺研究,2018,43(07):419-423.

[23] 李艳秋,王丽芹,郭闯,等.天枢穴结合头部足运感区埋线对脑卒中后便秘患者血清SP、VIP含量影响的研究[J].针灸临床杂志,2018,34(07):50-54.

[24] 陆琳. 电针深刺天枢穴治疗中风后便秘的临床疗效观察及其对血清SP、VIP含量的影响[D] :南京中医药大学,2017.

[25] 马宾. 脾气虚证大鼠小肠神经、Cajal间质细胞和平滑肌细胞形态学变化和针刺足三里、天枢穴修复作用实验研究[D] :大连医科大学,2014.

[26] 张伟. 基于肥大细胞活化-P物质关联性探讨电针治疗PI-IBS内脏高敏感的效应机制[D] :南京中医药大学,2014.

[27] Meng XM,Liu XT.[Effect of application of herbal medicine paste to “Tianshu” (ST25)on intestinal mobility and expression of vasoactive intestinal peptide and substance P in colonic myenteric plexus in rats with functional constipation][J].Zhen Ci Yan Jiu,2019,44(12):906-910.

[28] Chen Y,Zhao Y,Luo DN, et al.Electroacupuncture Regulates Disorders of Gut-Brain Interaction by Decreasing Corticotropin-Releasing Factor in a Rat Model of IBS[J].Gastroenterol Res Pract,2019,2019:1759842.

[29] Li ZY,Yang YT,Hong J, et al.Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion[J].Neural Regen Res,2017,12(9):1472-1478.

[30] Ma XP,Tan LY,Yang Y, et al.Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome[J].World J Gastroenterol,2009,15(41):5211-5217.

[31] Wu HG,Jiang B,Zhou EH, et al.Regulatory mechanism of electroacupuncture in irritable bowel syndrome: preventing MC activation and decreasing SP VIP secretion[J].Dig Dis Sci,2008,53(6):1644-1651.

[32] 魏小丽,王宇航,李成,等.针刺天枢穴联合莫沙必利治疗对习惯性便秘患者血清VIP、MTL、5-HT的影响[J].中华中医药学刊,:1-6.

[33] 秦瑶. 超声导入香砂六君子膏在OPCABG术后脾虚气滞型胃肠功能障碍的临床意义[D] :辽宁中医药大学,2019.

[34] 杨磊,孙洁,李滢,等.电针对IBS模型大鼠肠系膜微血管管径与血浆CGRP、VIP水平的影响[J].西部中医药,2014,27(03):22-25.

[35] 陈磊. 电针不同穴位对肠易激综合征模型大鼠肠道微循环、脑肠相关神经肽影响的研究[D] :北京中医药大学,2013.

[36] 杨磊,赵雅芳,李滢,等.电针不同穴位对肠易激综合征模型大鼠血浆CGRP、VIP、ET含量的影响[J].吉林中医药,2011,31(12):1235-1237.

[37] 齐晶晶,李志海,潘国宏,等.艾灸联合穴位注射对慢传输型便秘患者胃动素的影响[J].世界华人消化杂志,2011,19(09):976-980.

[38] 郝强,郝春华,庄贺.电针天枢穴和太冲穴对便秘型肠易激综合征模型小鼠5-羟色胺信号系统的影响[J].山东中医药大学学报,2020,44(01):69-72.

[39] Zhu X,Liu Z,Niu W, et al.Effects of electroacupuncture at ST25 and BL25 in a Sennae-induced rat model of diarrhoea-predominant irritable bowel syndrome[J].Acupunct Med,2017,35(3):216-223.

[40] Zhu X,Liu Z,Qin Y, et al.Analgesic effects of electroacupuncture at ST25 and CV12 in a rat model of postinflammatory irritable bowel syndrome visceral pain[J].Acupunct Med,2018,36(4):240-246.

[41] Liu HR,Wang XM,Zhou EH, et al.Acupuncture at both ST25 and ST37 improves the pain threshold of chronic visceral hypersensitivity rats[J].Neurochem Res,2009,34(11):1914-1918.

[42] 孙钊. 不同穴位配伍的电针治疗对D-IBS模型大鼠的效应差异[D] :山东中医药大学,2015.

[43] 何雨霞,储浩然,仝理,等.温和灸“上巨虚”“天枢”穴对肠易激综合征大鼠Orexin及Ox1R表达影响[J].辽宁中医药大学学报,2020,22(11):88-91.

[44] 邓海珊.针刺治疗肠易激综合征的临床观察及其对调节性T细胞功能的影响[J].分子影像学杂志,2016,39(03):251-253.

[45] 吴朝阳. 不同取穴法艾灸对UC大鼠肠黏膜组织形态及血清炎性因子含量的影响[D] :辽宁中医药大学,2009.

[46] Wang X,Liu Y,Dong H, et al.Herb-Partitioned Moxibustion Regulates the TLR2/NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis[J].Evid Based Complement Alternat Med,2015,2015:949065.

[47] 高妮娜.天枢穴药物敷贴联合硬膜外镇痛泵对痔疮术后患者疼痛VAS评分及血清β-内啡肽的影响[J].现代中西医结合杂志,2020,29(13):1456-1459.

[48] Leng J,Xiong F,Yao J, et al.Electroacupuncture Reduces Weight in Diet-Induced Obese Rats via Hypothalamic Tsc1 Promoter Demethylation and Inhibition of the Activity of mTORC1 Signaling Pathway[J].Evid Based Complement Alternat Med,2018,2018:3039783.

[49] 胡勇,汪新华,何超男,等.天枢穴贴敷对呼吸机相关性肺炎患者的呼吸力学与血清炎症因子的影响[J].中华医院感染学杂志,2019,29(19):2931-2934.

[50] 杨玲,黄艳,黄任佳,等.艾灸预处理天枢穴对溃疡性结肠炎大鼠结肠TLR4/TRIF信号通路调节作用的研究[J].上海针灸杂志,2019,38(08):819-826.

[51] Qi Q,Im H,Li KS, et al.Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative coliti[J].J Tradit Chin Med,2021,41(3):479-485.

[52] 李欣同. 一指禅推中脘、天枢穴对家兔血清GAS及生化的影响研究[D] :广州中医药大学,2016.

[53] 岳峰杰. 电针对功能性便秘大鼠胃肠及血清中GAS的影响[D] :陕西中医学院,2013.

[54] 马喆,方臻臻,吴焕淦,等.艾灸预处理“天枢”穴对溃疡性结肠炎大鼠肠黏膜屏障保护的机制研究[J].世界科学技术-中医药现代化,2018,20(09):1555-1563.

[55] 吴焕淦,刘慧荣,施茵,等.隔药灸对溃疡性结肠炎大鼠结肠IL-1β、IGF-1表达影响的研究[J].江西中医学院学报,2004,(06):56-60.

[56] 施征,马晓芃,吴焕淦,等.针灸调节大鼠溃疡性结肠炎结肠组织COX-2及IL-1β的研究[J].江西中医学院学报,2004,(03):38-40.

[57] Shang HX,Wang AQ,Bao CH, et al.Moxibustion combined with acupuncture increases tight junction protein expression in Crohn’s disease patients[J].World J Gastroenterol,2015,21(16):4986-4996.

[58] Bao CH,Wu LY,Shi Y, et al.Moxibustion down-regulates colonic epithelial cell apoptosis and repairs tight junctions in rats with Crohn’s disease[J].World J Gastroenterol,2011,17(45):4960-4970.

[59] 李凯歌,郭孟玮,谭莉华,等.比较电针“大肠俞”“天枢”穴对肠易激综合征模型大鼠内脏敏感性、Cajal间质细胞和辣椒素受体1的影响[J].中国针灸,2018,38(06):625-629+636.

[60] 孙思思. 电针不同穴位对功能性腹泻模型大鼠肠组织中c-kit mRNA表达的影响[D] :陕西中医药大学,2015.

[61] 孙建华,郭慧,裴丽霞,等.电针天枢穴对慢传输型便秘大鼠结肠c-kit、SCF基因表达的调节[J].南京中医药大学学报,2011,27(01):33-35.

[62] 谭莉华,李凯歌,吴艳英,等.电针“印堂”“天枢”穴对肠易激综合征大鼠行为学及结肠辣椒素受体的影响[J].针刺研究,2017,42(02):136-140+167.

[63] 崔晓. 电针对IBS模型大鼠ACC神经元放电及结肠TRPV1表达的影响[D] :北京中医药大学,2016.

[64] 崔云华,张明明,吴璐一,等. 不同温度艾灸对IBS模型大鼠内脏敏感性及天枢穴TRPV1、TRPV2蛋白表达的影响[A] ,2013.

[65] Yu Z,Zhang N,Lu CX, et al.Electroacupuncture at ST25 inhibits jejunal motility: Role of sympathetic pathways and TRPV1[J].World J Gastroenterol,2016,22(5):1834-1843.

[66] 王珊,郭孟玮,高誉珊,等.电针“内关”“天枢”穴对肠易激综合征大鼠结肠动力及结肠D 2受体的影响[J].针刺研究,2018,43(01):24-28.

[67] 李阳,郝艺照,傅熠俊,等.针刺天枢穴对结肠炎肠上皮细胞NF-κB信号通路的影响[J].中华中医药杂志,2017,32(11):5143-5147.

[68] 聂容荣,潘泓华,文辉,等.电针刺激天枢穴对急性重症胰腺炎大鼠肺组织AQP-1表达的影响[J].山东医药,2017,57(22):35-37.

[69] 谭莉华. 电针不同穴对IBS大鼠ACC神经元放电及NMDA受体表达的影响[D] :北京中医药大学,2017.

[70] Tan LH,Li KG,Wu YY, et al.Effect of Electroacupuncture at Different Acupoints on the Expression of NMDA Receptors in ACC and Colon in IBS Rats[J].Evid Based Complement Alternat Med,2019,2019:4213928.

[71] Wang LD,Zhao JM,Huang RJ, et al.Study on the Mechanism Underlying the Regulation of the NMDA Receptor Pathway in Spinal Dorsal Horns of Visceral Hypersensitivity Rats by Moxibustion[J].Evid Based Complement Alternat Med,2016,2016:3174608.

[72] 彭洪皓. 脾气虚证大鼠小肠肠神经-Cajal间质细胞-平滑肌网络损伤和针刺足三里、天枢穴修复作用的实验研究[D] :大连医科大学,2017.

[73] 黄艳,赵继梦,关鑫,等.温和灸对溃疡性结肠炎大鼠天枢穴P2RX_7的作用机理研究[J].世界科学技术-中医药现代化,2016,18(03):389-394.

[74] 陈磊,杨帅,杨磊,等.即刻电针介入对IBS模型大鼠血浆ET,CGRP水平及结肠ETR-A,CGRPmRNA表达的影响[J].现代生物医学进展,2013,13(34):6634-6637+6736.

[75] Liang C,Wang KY,Gong MR, et al.Electro-acupuncture at ST37 and ST25 induce different effects on colonic motility via the enteric nervous system by affecting excitatory and inhibitory neurons[J].Neurogastroenterol Motil,2018,30(7):e13318.

[76] 罗婧. 不同频率电针天枢穴对活动期湿热型溃疡性结肠炎大鼠模型免疫细胞及肠道上皮细胞的影响[D] :泸州医学院,2014.

[77] 朱文莲,李滢,张露芬,等.电针足三里和天枢穴对肠易激综合征大鼠脑肠轴不同靶点的效应差异[J].中华中医药杂志,2014,29(03):736-738.

[78] 口锁堂,吴焕淦. 艾灸对UC模型大鼠治疗效应及穴区Cx43表达影响的实验研[A] ,2012.

[79] 秦明,饶志仁,黄裕新,等.电针上巨虚、天枢穴对溃疡性结肠炎大鼠延髓Fos和GFAP表达的影响[J].中医药导报,2012,18(02):17-19+23.

[80] Wang SJ,Yang HY,Wang F, et al.Acupoint Specificity on Colorectal Hypersensitivity Alleviated by Acupuncture and the Correlation with the Brain-Gut Axis[J].Neurochem Res,2015,40(6):1274-1282.

[81] Iwa M,Tateiwa M,Sakita M, et al.Anatomical evidence of regional specific effects of acupuncture on gastric motor function in rats[J].Auton Neurosci,2007,137(1-2):67-76.

[82] Zhao M,Wang Z,Weng Z, et al.Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex[J].Evid Based Complement Alternat Med,2020,2020:2562979.

[83] 王永玲,高建芝,原志庆,等.针刺肥胖合并高脂血症大鼠时Bcl-2的变化对肝细胞凋亡的影响[J].陕西中医,2009,30(09):1249-1252.

[84] 陈楚淘,严杰,田浩梅,等.电针天枢配大肠俞、天枢配上巨虚对溃疡性结肠炎模型大鼠血清NO、MDA影响的比较研究[J].中医药导报,2008,14(12):1-3.

[85] 王荣,白海霞,冀来喜,等.电针天枢不同配穴对溃疡性结肠炎大鼠结肠黏膜保护作用的研究[J].世界中西医结合杂志,2007,(11):639-642.

[86] Ji MX,Guo MW,Gao YS, et al.[Comparison of effects of electroacupuncture at “Tianshu” (ST25) and “Dachangshu” (BL25) on intestinal sensitivity and expression of muscarinic M(3)R and 5-HT(3A)R in irritable bowel syndrome rats][J].Zhen Ci Yan Jiu,2019,44(4):264-269.

[87] Liu S,Wang ZF,Su YS, et al.Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture[J].Neuron,2020,108(3):436-450.e7.

[88] Zhao C,Qi L,Wu L, et al.Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity[J].Neural Regen Res,2012,7(15):1145-1150.

[89] Wang Q,Wang Y,Niu WM, et al.[Electroacupuncture improves intestinal function by down-regulating expression of 5-HT(1A)R and c-fos proteins in the hypothalamus and colon tissues via brain-gut axis in rats with functional diarrhea][J].Zhen Ci Yan Jiu,2019,44(7):501-505.

[90] Song YF,Pei LX,Chen L, et al.Electroacupuncture Relieves Irritable Bowel Syndrome by Regulating IL-18 and Gut Microbial Dysbiosis in a Trinitrobenzene Sulfonic Acid-Induced Post-Inflammatory Animal Model[J].Am J Chin Med,2020,48(1):77-90.

[91] Zhou EH,Wang XM,Ding GH, et al.Suspended moxibustion relieves chronic visceral hyperalgesia and decreases hypothalamic corticotropin-releasing hormone levels[J].World J Gastroenterol,2011,17(5):662-665.

[92] Shi Y,Li T,Zhou J, et al.Herbs-Partitioned Moxibustion Combined with Acupuncture Inhibits TGF-β1-Smad-Snail-Induced Intestinal Epithelial Mesenchymal Transition in Crohn’s Disease Model Rats[J].Evid Based Complement Alternat Med,2019,2019:8320250.

[93] Lu Y,Ding G,Zheng H, et al.Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease[J].J Tradit Chin Med,2019,39(3):356-363.

[94] Zhang F,Ma Z,Weng Z, et al.P2X(3) Receptor in Primary Afferent Neurons Mediates the Relief of Visceral Hypersensitivity by Electroacupuncture in an Irritable Bowel Syndrome Rat Model[J].Gastroenterol Res Pract,2020,2020:8186106.

[95] Weng Z,Wu L,Lu Y, et al.Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity[J].Neural Regen Res,2013,8(9):802-808.

[96] Weng ZJ,Wu LY,Zhou CL, et al.Effect of electroacupuncture on P2X3 receptor regulation in the peripheral and central nervous systems of rats with visceral pain caused by irritable bowel syndrome[J].Purinergic Signal,2015,11(3):321-329.

[97] Tang Q,Lu M,Xu B, et al.Electroacupuncture Regulates Inguinal White Adipose Tissue Browning by Promoting Sirtuin-1-Dependent PPARγ Deacetylation and Mitochondrial Biogenesis[J].Front Endocrinol (Lausanne),2020,11:607113.

[98] Xu J,Chen L,Tang L, et al.Electroacupuncture inhibits weight gain in diet-induced obese rats by activating hypothalamic LKB1-AMPK signaling[J].BMC Complement Altern Med,2015,15:147.

[99] Gao X,Zhao Y,Su Y, et al.β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints[J].PLoS One,2016,11(12):e0168200.

[100] Yi T,Qi L,Wu H, et al.Analgesic action of suspended moxibustion in rats with chronic visceral hyperalgesia correlates with enkephalins in the spinal cord[J].Neural Regen Res,2012,7(3):219-222.

[101] Qi L,Liu HR,Yi T, et al.Warming Moxibustion Relieves Chronic Visceral Hyperalgesia in Rats: Relations to Spinal Dynorphin and Orphanin-FQ System[J].Evid Based Complement Alternat Med,2013,2013:920675.